Ketamine is the prototype for a new generation of glutamate-based antidepressants that
rapidly alleviate depression within hours of treatment. Over the past decade, there has been
replicated evidence demonstrating the rapid and potent antidepressant effects of ketamine
in treatment-resistant depression. Moreover, preclinical and biomarker studies have begun
to elucidate the mechanism underlying the rapid antidepressant effects of ketamine, offering
a new window into the biology of depression and identifying a plethora of potential treatment …