Scopolamine rapidly increases mammalian target of rapamycin complex 1 signaling, synaptogenesis, and antidepressant behavioral responses
B Voleti, A Navarria, RJ Liu, M Banasr, N Li… - Biological …, 2013 - Elsevier
Background Clinical studies report that scopolamine, an acetylcholine muscarinic receptor
antagonist, produces rapid antidepressant effects in depressed patients, but the
mechanisms underlying the therapeutic response have not been determined. The present
study examines the role of the mammalian target of rapamycin complex 1 (mTORC1) and
synaptogenesis, which have been implicated in the rapid actions of N-methyl-D-aspartate
receptor antagonists. Methods The influence of scopolamine on mTORC1 signaling was …
antagonist, produces rapid antidepressant effects in depressed patients, but the
mechanisms underlying the therapeutic response have not been determined. The present
study examines the role of the mammalian target of rapamycin complex 1 (mTORC1) and
synaptogenesis, which have been implicated in the rapid actions of N-methyl-D-aspartate
receptor antagonists. Methods The influence of scopolamine on mTORC1 signaling was …