[PDF][PDF] Emerging concepts in organ-specific lymphatic vessels and metabolic regulation of lymphatic development

BW Wong, A Zecchin, M García-Caballero… - Developmental cell, 2018 - cell.com
Developmental cell, 2018cell.com
The lymphatic system has been less well characterized than the blood vascular system;
however, work in recent years has uncovered novel regulators and non-venous lineages
that contribute to lymphatic formation in various organs. Further, the identification of organ-
specific lymphatic beds underscores their potential interaction with organ development and
function, and highlights the possibility of targeting these organ-specific lymphatics beds in
disease. This review focuses on newly described metabolic and epigenetic regulators of …
The lymphatic system has been less well characterized than the blood vascular system; however, work in recent years has uncovered novel regulators and non-venous lineages that contribute to lymphatic formation in various organs. Further, the identification of organ-specific lymphatic beds underscores their potential interaction with organ development and function, and highlights the possibility of targeting these organ-specific lymphatics beds in disease. This review focuses on newly described metabolic and epigenetic regulators of lymphangiogenesis and the interplay between lymphatic development and function in a number of major organ systems.
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