The platelet-activating factor receptor activates the extracellular signal-regulated kinase mitogen-activated protein kinase and induces proliferation of epidermal cells …
SA Marques, LC Dy, MD Southall, Q Yi… - The Journal of …, 2002 - Elsevier
Platelet-activating factor (PAF) is a lipid mediator that has been implicated in a variety of
keratinocyte functions. Keratinocytes express the specific receptor for PAF (PAF-R), a seven-
transmembrane G-protein-coupled receptor. Although PAF-R-dependent stimulation of
numerous signal transduction pathways has been shown in a variety of cell types, to date
there has been no analysis of PAF-R signal transduction in human epidermal cells. There is
also contradictory evidence that PAF acts as either a suppressor or activator of keratinocyte …
keratinocyte functions. Keratinocytes express the specific receptor for PAF (PAF-R), a seven-
transmembrane G-protein-coupled receptor. Although PAF-R-dependent stimulation of
numerous signal transduction pathways has been shown in a variety of cell types, to date
there has been no analysis of PAF-R signal transduction in human epidermal cells. There is
also contradictory evidence that PAF acts as either a suppressor or activator of keratinocyte …