Endozepines

Z Farzampour, RJ Reimer, J Huguenard - Advances in Pharmacology, 2015 - Elsevier
Since their introduction in the 1960s, benzodiazepines (BZs) remain one of the most
commonly prescribed medications, acting as potent sedatives, hypnotics, anxiolytics,
anticonvulsants, and muscle relaxants. The primary neural action of BZs and related
compounds is augmentation of inhibitory transmission, which occurs through allosteric
modulation of the gamma-aminobutyric acid (GABA)-induced current at the gamma-
aminobutyric acid receptor (GABA AR). The discovery of the BZ-binding site on GABA A Rs …