[HTML][HTML] Production of reactive oxygen species by mitochondria: central role of complex III
Q Chen, EJ Vazquez, S Moghaddas, CL Hoppel… - Journal of Biological …, 2003 - ASBMB
The mitochondrial respiratory chain is a major source of reactive oxygen species (ROS)
under pathological conditions including myocardial ischemia and reperfusion. Limitation of
electron transport by the inhibitor rotenone immediately before ischemia decreases the
production of ROS in cardiac myocytes and reduces damage to mitochondria. We asked if
ROS generation by intact mitochondria during the oxidation of complex I substrates
(glutamate, pyruvate/malate) occurred from complex I or III. ROS production by mitochondria …
under pathological conditions including myocardial ischemia and reperfusion. Limitation of
electron transport by the inhibitor rotenone immediately before ischemia decreases the
production of ROS in cardiac myocytes and reduces damage to mitochondria. We asked if
ROS generation by intact mitochondria during the oxidation of complex I substrates
(glutamate, pyruvate/malate) occurred from complex I or III. ROS production by mitochondria …