Conjugated equine estrogens and incidence of probable dementia and mild cognitive impairment in postmenopausal women: Women's Health Initiative Memory …
SA Shumaker, C Legault, L Kuller, SR Rapp, L Thal… - Jama, 2004 - jamanetwork.com
ContextThe Women's Health Initiative Memory Study (WHIMS) previously found increased
risk for dementia and no effect on mild cognitive impairment (MCI) in women treated with
conjugated equine estrogens (CEE) plus medroxyprogesterone acetate (MPA). ObjectiveTo
determine the effects of CEE alone and CEE plus MPA on incidence of probable dementia
and MCI in older women. Design, Setting, and ParticipantsRandomized, double-blind,
placebo-controlled clinical trials of CEE (estrogen-alone trial) or CEE plus MPA (estrogen …
risk for dementia and no effect on mild cognitive impairment (MCI) in women treated with
conjugated equine estrogens (CEE) plus medroxyprogesterone acetate (MPA). ObjectiveTo
determine the effects of CEE alone and CEE plus MPA on incidence of probable dementia
and MCI in older women. Design, Setting, and ParticipantsRandomized, double-blind,
placebo-controlled clinical trials of CEE (estrogen-alone trial) or CEE plus MPA (estrogen …