Effect of estrogen plus progestin on global cognitive function in postmenopausal women: the Women's Health Initiative Memory Study: a randomized controlled trial

SR Rapp, MA Espeland, SA Shumaker, VW Henderson… - Jama, 2003 - jamanetwork.com
ContextObservational studies have suggested that postmenopausal hormone treatment may
improve cognitive function, but data from randomized clinical trials have been sparse and
inconclusive. The Women's Health Initiative Memory Study (WHIMS) is an ancillary study of
the Women's Health Initiative (WHI) hormone therapy trials. On July 8, 2002, the estrogen
plus progestin therapy in the WHI trial was discontinued because of certain increased health
risks for women. ObjectiveTo determine whether estrogen plus progestin therapy protects …