[HTML][HTML] Neuralized-like 1 (Neurl1) targeted to the plasma membrane by N-myristoylation regulates the Notch ligand Jagged1
E Koutelou, S Sato, C Tomomori-Sato, L Florens… - Journal of biological …, 2008 - ASBMB
Notch signaling constitutes an evolutionarily conserved mechanism that mediates cell-cell
interactions in various developmental processes. Numerous regulatory proteins interact with
the Notch receptor and its ligands and control signaling at multiple levels. Ubiquitination and
endocytosis followed by endosomal sorting of both the receptor and its ligands is essential
for Notch-mediated signaling. The E3 ubiquitin ligases, Neuralized (Neur) and Mind Bomb
(Mib1), are crucial for regulating the activity and stability of Notch ligands in Drosophila; …
interactions in various developmental processes. Numerous regulatory proteins interact with
the Notch receptor and its ligands and control signaling at multiple levels. Ubiquitination and
endocytosis followed by endosomal sorting of both the receptor and its ligands is essential
for Notch-mediated signaling. The E3 ubiquitin ligases, Neuralized (Neur) and Mind Bomb
(Mib1), are crucial for regulating the activity and stability of Notch ligands in Drosophila; …