[HTML][HTML] Identification of a cytochrome P4502E1/Bid/C1q-dependent axis mediating inflammation in adipose tissue after chronic ethanol feeding to mice
BM Sebastian, S Roychowdhury, H Tang… - Journal of Biological …, 2011 - ASBMB
Chronic, heavy alcohol exposure results in inflammation in adipose tissue, insulin
resistance, and liver injury. Here we have identified a CYP2E1/Bid/C1q-dependent pathway
that is activated in response to chronic ethanol and is required for the development of
inflammation in adipose tissue. Ethanol feeding for 25 days to wild-type (C57BL/6J) mice
increased expression of multiple markers of adipose tissue inflammation relative to pair-fed
controls independent of increased body weight or adipocyte size. Ethanol feeding increased …
resistance, and liver injury. Here we have identified a CYP2E1/Bid/C1q-dependent pathway
that is activated in response to chronic ethanol and is required for the development of
inflammation in adipose tissue. Ethanol feeding for 25 days to wild-type (C57BL/6J) mice
increased expression of multiple markers of adipose tissue inflammation relative to pair-fed
controls independent of increased body weight or adipocyte size. Ethanol feeding increased …
