Evaluation of tumor-infiltrating lymphocytes using routine H&E slides predicts patient survival in resected non–small cell lung cancer

M Rakaee, TK Kilvaer, SM Dalen, E Richardsen… - Human pathology, 2018 - Elsevier
The presence of tumor-infiltrating lymphocytes (TILs) positively impacts the outcome of non–
small cell lung cancer (NSCLC) patients. Most previous studies have assessed TILs using
different immunohistochemical assays. The purpose of this study was to develop and
validate a histopathological scoring model for the assessment of TILs in whole-tissue
hematoxylin and eosin (H&E)–stained section slides of NSCLC patients and to evaluate the
model in an immunoscore setting. Therefore, TIL was evaluated manually on H&E slides …