ONYX-015: mechanisms of action and clinical potential of a replication-selective adenovirus

S Ries, WM Korn - British journal of cancer, 2002 - nature.com
S Ries, WM Korn
British journal of cancer, 2002nature.com
Accumulated knowledge in the molecular processes of tumour development combined with
the availability of genetically modified viruses resemble the basis for new promising cancer
therapeutics. The main advantages of employing replication-competent viruses are
achievement of tumour selective killing and amplification of their oncolytic potential within
the tumour mass. In this review, we describe the development of ONYX-015, one of the first
and most advanced replication-competent viruses for cancer therapy. We discuss the …
Abstract
Accumulated knowledge in the molecular processes of tumour development combined with the availability of genetically modified viruses resemble the basis for new promising cancer therapeutics. The main advantages of employing replication-competent viruses are achievement of tumour selective killing and amplification of their oncolytic potential within the tumour mass. In this review, we describe the development of ONYX-015, one of the first and most advanced replication-competent viruses for cancer therapy. We discuss the molecular biology of this therapeutic approach and the interesting results obtained with this virus in clinical trials.
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