Peptidylarginine deiminase inhibition disrupts NET formation and protects against kidney, skin and vascular disease in lupus-prone MRL/lpr mice
JS Knight, V Subramanian, AA O'Dell… - Annals of the rheumatic …, 2015 - Elsevier
Objectives An imbalance between neutrophil extracellular trap (NET) formation and
degradation has been described in systemic lupus erythematosus (SLE), potentially
contributing to autoantigen externalisation, type I interferon synthesis and endothelial
damage. We have demonstrated that peptidylarginine deiminase (PAD) inhibition reduces
NET formation and protects against lupus-related vascular damage in the New Zealand
Mixed model of lupus. However, another strategy for inhibiting NETs—knockout of NOX2 …
degradation has been described in systemic lupus erythematosus (SLE), potentially
contributing to autoantigen externalisation, type I interferon synthesis and endothelial
damage. We have demonstrated that peptidylarginine deiminase (PAD) inhibition reduces
NET formation and protects against lupus-related vascular damage in the New Zealand
Mixed model of lupus. However, another strategy for inhibiting NETs—knockout of NOX2 …