Exosomal microRNA clusters are important for the therapeutic effect of cardiac progenitor cells

JPG Sluijter, E Van Rooij - Circulation research, 2015 - Am Heart Assoc
Circulation research, 2015Am Heart Assoc
Circulating miRNAs have also shown to be relevant for coronary heart disease. Patients with
coronary heart disease showed a less efficient transfer of miRNAs to cultured HUVECs
(human vascular endothelial cells), which may contribute to the abnormal intercellular
communication that underlies coronary heart disease initiation and progression. 10 This
underscores that appropriate delivery of miRNAs is required to maintain healthy conditions.
Exosomes derived from cardiac stem or progenitor cells in general seem to elicit a more …
Circulating miRNAs have also shown to be relevant for coronary heart disease. Patients with coronary heart disease showed a less efficient transfer of miRNAs to cultured HUVECs (human vascular endothelial cells), which may contribute to the abnormal intercellular communication that underlies coronary heart disease initiation and progression. 10 This underscores that appropriate delivery of miRNAs is required to maintain healthy conditions. Exosomes derived from cardiac stem or progenitor cells in general seem to elicit a more beneficial response. 11 Recently, it was shown that the regenerative effect of cardiosphere-derived cells in response to cardiac ischemic injury is largely dependent on exosomal transfer of miR-146a, and that cardiospherederived exosomes alone are sufficient to confer the same effects as the cardiosphere-derived cells themselves, whereas miR-146a alone did not. 12 Also exosomes coming from mesenchymal stem cells showed to contain an increased amount of several miRNAs in response to preconditioning. Injecting these preconditioned exosomes resulted in less apoptosis and remodeling after myocardial infarction, 13 an effect that was largely contributed to the exosomal delivery of miR-22 to neighboring cells. 14
Am Heart Assoc