Long-term functional benefits of human embryonic stem cell-derived cardiac progenitors embedded into a fibrin scaffold
V Bellamy, V Vanneaux, A Bel, H Nemetalla… - The Journal of Heart and …, 2015 - Elsevier
Background Cardiac-committed cells and biomimetic scaffolds independently improve the
therapeutic efficacy of stem cells. In this study we tested the long-term effects of their
combination. Methods Eighty immune-deficient rats underwent permanent coronary artery
ligation. Five to 7 weeks later, those with an echocardiographically measured ejection
fraction (EF)≤ 55% were re-operated on and randomly allocated to receive a cell-free fibrin
patch (n= 25), a fibrin patch loaded with 700,000 human embryonic stem cells (ESC) pre …
therapeutic efficacy of stem cells. In this study we tested the long-term effects of their
combination. Methods Eighty immune-deficient rats underwent permanent coronary artery
ligation. Five to 7 weeks later, those with an echocardiographically measured ejection
fraction (EF)≤ 55% were re-operated on and randomly allocated to receive a cell-free fibrin
patch (n= 25), a fibrin patch loaded with 700,000 human embryonic stem cells (ESC) pre …