[HTML][HTML] Opioid agonists have different efficacy profiles for G protein activation, rapid desensitization, and endocytosis of mu-opioid receptors
SL Borgland, M Connor, PB Osborne… - Journal of Biological …, 2003 - ASBMB
The differential ability of various μ-opioid receptor (MOP) agonists to induce rapid receptor
desensitization and endocytosis of MOP could arise simply from differences in their efficacy
to activate G proteins or, alternatively, be due to differential capacity for activation of other
signaling processes. We used AtT20 cells stably expressing a low density of FLAG-tagged
MOP to compare the efficacies of a range of agonists to 1) activate G proteins using
inhibition of calcium channel currents (I Ca) as a reporter before and after inactivation of a …
desensitization and endocytosis of MOP could arise simply from differences in their efficacy
to activate G proteins or, alternatively, be due to differential capacity for activation of other
signaling processes. We used AtT20 cells stably expressing a low density of FLAG-tagged
MOP to compare the efficacies of a range of agonists to 1) activate G proteins using
inhibition of calcium channel currents (I Ca) as a reporter before and after inactivation of a …