[HTML][HTML] The 9p21 locus and coronary heart disease: initiator, promoter, or precipitator?

JL Anderson, BD Horne - Journal of the American College of Cardiology, 2010 - jacc.org
JL Anderson, BD Horne
Journal of the American College of Cardiology, 2010jacc.org
Coronary heart disease (CHD), a major cause of worldwide morbidity/mortality (1), is a
multifactorial, multistage disorder to which both environmental and genetic factors contribute
(Fig. 1)(2). Despite methodologic advances, including genomewide association studies,
progress in elucidating CHD genetics has been slow, and the number and impact of well-
validated associations remain few and modest. One of the major successes in this effort has
been the discovery of the CHD risk-associated locus at chromosome 9p21. 3. First reported …
Coronary heart disease (CHD), a major cause of worldwide morbidity/mortality (1), is a multifactorial, multistage disorder to which both environmental and genetic factors contribute (Fig. 1)(2). Despite methodologic advances, including genomewide association studies, progress in elucidating CHD genetics has been slow, and the number and impact of well-validated associations remain few and modest. One of the major successes in this effort has been the discovery of the CHD risk-associated locus at chromosome 9p21. 3. First reported by several groups in 2007 (3–6), this association subsequently has been validated by multiple groups worldwide, across racial and geographic boundaries, and independent of traditional risk factors (7).
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