β-catenin-independent roles of Wnt/LRP6 signaling

SP Acebron, C Niehrs - Trends in cell biology, 2016 - cell.com
SP Acebron, C Niehrs
Trends in cell biology, 2016cell.com
Wnt/LRP6 signaling is best known for the β-catenin-dependent regulation of target genes.
However, pathway branches have recently emerged, including Wnt/STOP signaling, which
act independently of β-catenin and transcription. We review here the molecular mechanisms
underlying β-catenin-independent Wnt/LRP6 signaling cascades and their implications for
cell biology, development, and physiology.
Wnt/LRP6 signaling is best known for the β-catenin-dependent regulation of target genes. However, pathway branches have recently emerged, including Wnt/STOP signaling, which act independently of β-catenin and transcription. We review here the molecular mechanisms underlying β-catenin-independent Wnt/LRP6 signaling cascades and their implications for cell biology, development, and physiology.
cell.com