Isolated limb perfusion with TNFα and melphalan in a rat osteosarcoma model: a new anti-tumour approach
ER Manusama, J Stavast, NMC Durante… - European Journal of …, 1996 - Elsevier
Isolated limb perfusion (ILP) with TNFα, IFNγ and melphalan causes impressive tumour
reduction in patients with irresectable soft tissue sarcomas with a high limb salvage rate.
Since this therapy could be of value in patients with progressive osteosarcoma, we
performed a study in an osteosarcoma tumour model in the rat. The ROS-1 osteosarcoma
was implanted sc in the hind leg of WAG rats. Rats were divided in four groups: rats that
underwent ILP with perfusate alone, TNFα alone, melphalan alone or their combination …
reduction in patients with irresectable soft tissue sarcomas with a high limb salvage rate.
Since this therapy could be of value in patients with progressive osteosarcoma, we
performed a study in an osteosarcoma tumour model in the rat. The ROS-1 osteosarcoma
was implanted sc in the hind leg of WAG rats. Rats were divided in four groups: rats that
underwent ILP with perfusate alone, TNFα alone, melphalan alone or their combination …