Induction of cytotoxic T cells as a novel independent survival factor in malignant melanoma with percutaneous peptide immunization

T Fujiyama, I Oze, H Yagi, H Hashizume… - Journal of …, 2014 - Elsevier
Background Malignant melanoma (MM) often shows multiple chemo-resistance, leading to
poor prognosis of the patients. Therapeutic anti-cancer vaccination may be a feasible way to
prolong the survival of patients. We have demonstrated that application of antigenic peptides
via the tape-stripped, horny layer-removed skin, known as percutaneous peptide
immunization (PPI), induces tumor cell-specific cytotoxic T lymphocytes (CTLs) in rodents
and humans. Objective To evaluate clinical significance of PPI in advanced MM patients …