Micromanagement of the immune system by microRNAs

HF Lodish, B Zhou, G Liu, CZ Chen - Nature Reviews Immunology, 2008 - nature.com
HF Lodish, B Zhou, G Liu, CZ Chen
Nature Reviews Immunology, 2008nature.com
MicroRNAs (miRNAs) are an abundant class of evolutionarily conserved small non-coding
RNAs that are thought to control gene expression by targeting mRNAs for degradation or
translational repression. Emerging evidence suggests that miRNA-mediated gene
regulation represents a fundamental layer of genetic programmes at the post-transcriptional
level and has diverse functional roles in animals. Here, we provide an overview of the
mechanisms by which miRNAs regulate gene expression, with specific focus on the role of …
Abstract
MicroRNAs (miRNAs) are an abundant class of evolutionarily conserved small non-coding RNAs that are thought to control gene expression by targeting mRNAs for degradation or translational repression. Emerging evidence suggests that miRNA-mediated gene regulation represents a fundamental layer of genetic programmes at the post-transcriptional level and has diverse functional roles in animals. Here, we provide an overview of the mechanisms by which miRNAs regulate gene expression, with specific focus on the role of miRNAs in regulating the development of immune cells and in modulating innate and adaptive immune responses.
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