[HTML][HTML] Cancer immunotherapy targeting neoantigens
YC Lu, PF Robbins - Seminars in immunology, 2016 - Elsevier
YC Lu, PF Robbins
Seminars in immunology, 2016•ElsevierNeoantigens are antigens encoded by tumor-specific mutated genes. Studies in the past few
years have suggested a key role for neoantigens in cancer immunotherapy. Here we review
the discoveries of neoantigens in the past two decades and the current advances in
neoantigen identification. We also discuss the potential benefits and obstacles to the
development of effective cancer immunotherapies targeting neoantigens.
years have suggested a key role for neoantigens in cancer immunotherapy. Here we review
the discoveries of neoantigens in the past two decades and the current advances in
neoantigen identification. We also discuss the potential benefits and obstacles to the
development of effective cancer immunotherapies targeting neoantigens.
Abstract
Neoantigens are antigens encoded by tumor-specific mutated genes. Studies in the past few years have suggested a key role for neoantigens in cancer immunotherapy. Here we review the discoveries of neoantigens in the past two decades and the current advances in neoantigen identification. We also discuss the potential benefits and obstacles to the development of effective cancer immunotherapies targeting neoantigens.
Elsevier