HDAC inhibitors TSA and sodium butyrate enhanced the human IL-5 expression by altering histone acetylation status at its promoter region

S Han, J Lu, Y Zhang, C Cheng, L Li, L Han, B Huang - Immunology letters, 2007 - Elsevier
The expression of IL-5 correlated tightly with the maturation and differentiation of
eosinophils, and is considered as a cytokine responsible for allergic inflammation. We report
here that inhibition of HDAC activity by Trichostatin A (TSA) and sodium butyrate (NaBu), the
two specific HDAC inhibitors, resulted in the elevation of both endogenous and exogenous
activity of IL-5 promoter. We demonstrated that both the mRNA expression and protein
production of IL-5 were stimulated by TSA and NaBu treatments. ChIP assays showed that …