Cloning of a novel interleukin (IL)-20-like gene in rainbow trout Oncorhynchus mykiss gives an insight into the evolution of the IL-10 family

T Wang, P Díaz-Rosales, SAM Martin… - Developmental & …, 2010 - Elsevier
A novel IL-20-like (IL-20L) gene has been analyzed in rainbow trout. It has a six exon/five
intron gene organisation and is translated into 181 amino acids (aa) with a signal peptide of
25aa and a mature peptide of 156aa. The trout IL-20L translation shares highest identities to
other IL-20L molecules from fish and to IL-20 in mammals. Phylogenetic analysis showed
that the fish IL-20L molecules form an independent clade but cluster with the group
containing the IL-19, IL-20 and IL-24 molecules from higher vertebrates with a high …