[HTML][HTML] Dichotomy of short and long thymic stromal lymphopoietin isoforms in inflammatory disorders of the bowel and skin
G Fornasa, K Tsilingiri, F Caprioli, F Botti… - Journal of Allergy and …, 2015 - Elsevier
Background Thymic stromal lymphopoietin (TSLP) is a cytokine with pleiotropic functions in
the immune system. It has been associated with allergic reactions in the skin and lungs but
also homeostatic tolerogenic responses in the thymus and gut. Objective In human subjects
TSLP is present in 2 isoforms, short and long. Here we wanted to investigate the differential
expression of the TSLP isoforms and discern their biological implications under homeostatic
or inflammatory conditions. Methods We evaluated the expression of TSLPs in tissues from …
the immune system. It has been associated with allergic reactions in the skin and lungs but
also homeostatic tolerogenic responses in the thymus and gut. Objective In human subjects
TSLP is present in 2 isoforms, short and long. Here we wanted to investigate the differential
expression of the TSLP isoforms and discern their biological implications under homeostatic
or inflammatory conditions. Methods We evaluated the expression of TSLPs in tissues from …