[HTML][HTML] Highly prevalent colorectal cancer-infiltrating LAP+ Foxp3− T cells exhibit more potent immunosuppressive activity than Foxp3+ regulatory T cells
Abstract Although elevated CD4+ Foxp3+ regulatory T cell (Treg) frequencies within tumors
are well documented, the functional and phenotypic characteristics of CD4+ Foxp3+ and
CD4+ Foxp3− T cell subsets from matched blood, healthy colon, and colorectal cancer
require in-depth investigation. Flow cytometry revealed that the majority of intratumoral
CD4+ Foxp3+ T cells (Tregs) were Helios+ and expressed higher levels of cytotoxic T-
lymphocyte antigen 4 (CTLA-4) and CD39 than Tregs from colon and blood. Moreover,∼ …
are well documented, the functional and phenotypic characteristics of CD4+ Foxp3+ and
CD4+ Foxp3− T cell subsets from matched blood, healthy colon, and colorectal cancer
require in-depth investigation. Flow cytometry revealed that the majority of intratumoral
CD4+ Foxp3+ T cells (Tregs) were Helios+ and expressed higher levels of cytotoxic T-
lymphocyte antigen 4 (CTLA-4) and CD39 than Tregs from colon and blood. Moreover,∼ …