[HTML][HTML] Preclinical mouse models of osteosarcoma

Ö Uluçkan, A Segaliny, S Botter, JM Santiago… - BoneKEy …, 2015 - ncbi.nlm.nih.gov
Ö Uluçkan, A Segaliny, S Botter, JM Santiago, AJ Mutsaers
BoneKEy reports, 2015ncbi.nlm.nih.gov
Osteosarcoma is the most common form of primary bone tumors with high prevalence in
children. Survival rates of osteosarcoma are low, especially in the case of metastases.
Mouse models of this disease have been very valuable in investigation of mechanisms of
tumorigenesis, metastasis, as well as testing possible therapeutic options. In this chapter, we
summarize currently available mouse models for osteosarcoma and provide detailed
methodology for the isolation of cell lines from genetically engineered mouse models …
Abstract
Osteosarcoma is the most common form of primary bone tumors with high prevalence in children. Survival rates of osteosarcoma are low, especially in the case of metastases. Mouse models of this disease have been very valuable in investigation of mechanisms of tumorigenesis, metastasis, as well as testing possible therapeutic options. In this chapter, we summarize currently available mouse models for osteosarcoma and provide detailed methodology for the isolation of cell lines from genetically engineered mouse models (GEMMs), gene modification and tumor cell injection methods, as well as imaging techniques.
ncbi.nlm.nih.gov