Effect of a 48-hour intravenous Δ4-androstenedione infusion on the pregnant rhesus monkey in the last third of gestation: Changes in maternal plasma estradiol …

JP Figueroa, MBOM Honnebier, Z Binienda… - American journal of …, 1989 - Elsevier
Increased myometrial activity in the pregnant rhesus monkey occurs in situations in which
plasma estrogen concentrations are elevated. Examples of such situations are after
laparotomy, with or without hysterotomy, and before delivery. The increased activity occurs
primarily in the hours of darkness. To investigate the possibility of a causal relationship
between the rise in estrogens and myometrial activity, we infused androstenedione
intravenously for 48 hours to the rhesus monkey in the last third of gestation. Myometrial …