The vesicular ATPase: a missing link between acidification and exocytosis
D Wang, PR Hiesinger - Journal of Cell Biology, 2013 - rupress.org
D Wang, PR Hiesinger
Journal of Cell Biology, 2013•rupress.orgThe vesicular adenosine triphosphatase (ATPase) acidifies intracellular compartments,
including synaptic vesicles and secretory granules. A controversy about a second function of
this ATPase in exocytosis has been fuelled by questions about multiple putative roles of
acidification in the exocytic process. Now, Poëa-Guyon et al.(2013. J. Cell Biol. http://dx. doi.
org/10.1083/jcb. 201303104) present new evidence that the vesicular ATPase performs
separate acidification and exocytosis roles and propose a mechanism for how these two …
including synaptic vesicles and secretory granules. A controversy about a second function of
this ATPase in exocytosis has been fuelled by questions about multiple putative roles of
acidification in the exocytic process. Now, Poëa-Guyon et al.(2013. J. Cell Biol. http://dx. doi.
org/10.1083/jcb. 201303104) present new evidence that the vesicular ATPase performs
separate acidification and exocytosis roles and propose a mechanism for how these two …
The vesicular adenosine triphosphatase (ATPase) acidifies intracellular compartments, including synaptic vesicles and secretory granules. A controversy about a second function of this ATPase in exocytosis has been fuelled by questions about multiple putative roles of acidification in the exocytic process. Now, Poëa-Guyon et al. (2013. J. Cell Biol. http://dx.doi.org/10.1083/jcb.201303104) present new evidence that the vesicular ATPase performs separate acidification and exocytosis roles and propose a mechanism for how these two functions are causally linked.
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