[HTML][HTML] IκBβ, but not IκBα, functions as a classical cytoplasmic inhibitor of NF-κB dimers by masking both NF-κB nuclear localization sequences in resting cells
NF-κB dimers, inhibitor IκB proteins, and NF-κB· IκB complexes exhibit distinct patterns in
partitioning between nuclear and cytoplasmic cellular compartments. IκB-dependent
modulation of NF-κB subcellular localization represents one of the more poorly understood
processes in the NF-κB signaling pathway. In this study, we have combined in vitro
biochemical and cell-based methods to elucidate differences in NF-κB regulation exhibited
by the inhibitors IκBβ and IκBα. We show that although both IκBα and IκBβ bind to NF-κB …
partitioning between nuclear and cytoplasmic cellular compartments. IκB-dependent
modulation of NF-κB subcellular localization represents one of the more poorly understood
processes in the NF-κB signaling pathway. In this study, we have combined in vitro
biochemical and cell-based methods to elucidate differences in NF-κB regulation exhibited
by the inhibitors IκBβ and IκBα. We show that although both IκBα and IκBβ bind to NF-κB …