Insulin signalling and the regulation of glucose and lipid metabolism

AR Saltiel, CR Kahn - Nature, 2001 - nature.com
Nature, 2001nature.com
The epidemic of type 2 diabetes and impaired glucose tolerance is one of the main causes
of morbidity and mortality worldwide. In both disorders, tissues such as muscle, fat and liver
become less responsive or resistant to insulin. This state is also linked to other common
health problems, such as obesity, polycystic ovarian disease, hyperlipidaemia, hypertension
and atherosclerosis. The pathophysiology of insulin resistance involves a complex network
of signalling pathways, activated by the insulin receptor, which regulates intermediary …
Abstract
The epidemic of type 2 diabetes and impaired glucose tolerance is one of the main causes of morbidity and mortality worldwide. In both disorders, tissues such as muscle, fat and liver become less responsive or resistant to insulin. This state is also linked to other common health problems, such as obesity, polycystic ovarian disease, hyperlipidaemia, hypertension and atherosclerosis. The pathophysiology of insulin resistance involves a complex network of signalling pathways, activated by the insulin receptor, which regulates intermediary metabolism and its organization in cells. But recent studies have shown that numerous other hormones and signalling events attenuate insulin action, and are important in type 2 diabetes.
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