Neuromyelitis optica brain lesions localized at sites of high aquaporin 4 expression
SJ Pittock, BG Weinshenker, CF Lucchinetti… - Archives of …, 2006 - jamanetwork.com
Background Neuromyelitis optica (NMO)–IgG is a specific autoantibody marker for NMO. It
binds selectively to aquaporin 4 (AQP4), which is highly concentrated in astrocytic foot
processes at the blood-brain barrier and is not restricted to optic nerve and spinal cord.
Although it is conventionally believed that the brain is spared, brain imaging abnormalities
are not uncommon in patients with NMO. Objective To investigate the location of brain
lesions that are distinctive for NMO with respect to the localization of AQP4 in mammalian …
binds selectively to aquaporin 4 (AQP4), which is highly concentrated in astrocytic foot
processes at the blood-brain barrier and is not restricted to optic nerve and spinal cord.
Although it is conventionally believed that the brain is spared, brain imaging abnormalities
are not uncommon in patients with NMO. Objective To investigate the location of brain
lesions that are distinctive for NMO with respect to the localization of AQP4 in mammalian …