Prediction of neuromyelitis optica attack severity by quantitation of complement-mediated injury to aquaporin-4–expressing cells
SR Hinson, A McKeon, JP Fryer… - Archives of …, 2009 - jamanetwork.com
Background Recent reports support a pathogenic role in neuromyelitis optica (NMO) for the
aquaporin-4 (AQP4)–specific autoantibody (NMO-IgG). Neuromyelitis optica is an
inflammatory demyelinating central nervous system disease, usually relapsing, that causes
variable degrees of attack-related disability. The NMO-IgG binds in vitro to the extracellular
domain of AQP4, activates complement, and causes astrocyte lesioning. Objective To
compare the prognostic utility of NMO-IgG titer and quantitative measures of complement …
aquaporin-4 (AQP4)–specific autoantibody (NMO-IgG). Neuromyelitis optica is an
inflammatory demyelinating central nervous system disease, usually relapsing, that causes
variable degrees of attack-related disability. The NMO-IgG binds in vitro to the extracellular
domain of AQP4, activates complement, and causes astrocyte lesioning. Objective To
compare the prognostic utility of NMO-IgG titer and quantitative measures of complement …