Bak deficiency inhibits liver carcinogenesis: a causal link between apoptosis and carcinogenesis
H Hikita, T Kodama, S Shimizu, W Li, M Shigekawa… - Journal of …, 2012 - Elsevier
BACKGROUND & AIMS: Hepatocyte apoptosis is a key feature of chronic liver disease
including viral hepatitis and steatohepatitis. A previous study demonstrated that absence of
the Bcl-2 family protein Mcl-1 led to increased hepatocyte apoptosis and development of
liver tumors in mice. Since Mcl-1 not only inhibits the mitochondrial pathway of apoptosis but
can also inhibit cell cycle progression and promote DNA repair, it remains to be proven
whether the tumor suppressive effects of Mcl-1 are mediated by prevention of apoptosis …
including viral hepatitis and steatohepatitis. A previous study demonstrated that absence of
the Bcl-2 family protein Mcl-1 led to increased hepatocyte apoptosis and development of
liver tumors in mice. Since Mcl-1 not only inhibits the mitochondrial pathway of apoptosis but
can also inhibit cell cycle progression and promote DNA repair, it remains to be proven
whether the tumor suppressive effects of Mcl-1 are mediated by prevention of apoptosis …