[HTML][HTML] A new NFIA: RAF1 fusion activating the MAPK pathway in pilocytic astrocytoma
CW Yde, A Sehested, À Mateu-Regué, O Østrup… - Cancer genetics, 2016 - Elsevier
Highlights•This study reports the discovery of a novel fusion in a recurrent pilocytic
astrocytoma.•The NFIA: RAF1 fusion results in constitutive Raf-1 kinase activity, leading to
activation of downstream MEK1/2.•These findings will contribute to the current diagnostics of
pediatric patients suffering from CNS-tumors.Pilocytic astrocytoma (PA) is one of the most
common brain cancers among children and activation of the Mitogen-Activated Protein
Kinase (MAPK) pathway is considered the hallmark. In the majority of cases, oncogenic …
astrocytoma.•The NFIA: RAF1 fusion results in constitutive Raf-1 kinase activity, leading to
activation of downstream MEK1/2.•These findings will contribute to the current diagnostics of
pediatric patients suffering from CNS-tumors.Pilocytic astrocytoma (PA) is one of the most
common brain cancers among children and activation of the Mitogen-Activated Protein
Kinase (MAPK) pathway is considered the hallmark. In the majority of cases, oncogenic …