[HTML][HTML] AMP-activated kinase (AMPK) promotes innate immunity and antiviral defense through modulation of stimulator of interferon genes (STING) signaling

D Prantner, DJ Perkins, SN Vogel - Journal of Biological Chemistry, 2017 - ASBMB
The host protein Stimulator of Interferon Genes (STING) has been shown to be essential for
recognition of both viral and intracellular bacterial pathogens, but its regulation remains
unclear. Previously, we reported that mitochondrial membrane potential regulates STING-
dependent IFN-β induction independently of ATP synthesis. Because mitochondrial
membrane potential controls calcium homeostasis, and AMP-activated protein kinase
(AMPK) is regulated, in part, by intracellular calcium, we postulated that AMPK participates …