MiR‐151a is involved in the pathogenesis of atopic dermatitis by regulating interleukin‐12 receptor β2
XF Chen, LJ Zhang, J Zhang, X Dou… - Experimental …, 2018 - Wiley Online Library
XF Chen, LJ Zhang, J Zhang, X Dou, Y Shao, XJ Jia, W Zhang, B Yu
Experimental Dermatology, 2018•Wiley Online LibraryMicro RNA s (mi RNA s) have been reported to circulate in the blood in a highly stable and
cell‐free form. Dysregulated expression of mi RNA s has been detected in various
pathological conditions including atopic dermatitis. In our study, human blood plasma mi
RNA s were identified by high‐throughput sequencing and compared among patients of
atopic dermatitis and healthy controls. We found that miR‐151a was differentially expressed
in the plasma of atopic dermatitis patients. MiR‐151a regulates the expression of IL 12 RB 2 …
cell‐free form. Dysregulated expression of mi RNA s has been detected in various
pathological conditions including atopic dermatitis. In our study, human blood plasma mi
RNA s were identified by high‐throughput sequencing and compared among patients of
atopic dermatitis and healthy controls. We found that miR‐151a was differentially expressed
in the plasma of atopic dermatitis patients. MiR‐151a regulates the expression of IL 12 RB 2 …
Abstract
MicroRNAs (miRNAs) have been reported to circulate in the blood in a highly stable and cell‐free form. Dysregulated expression of miRNAs has been detected in various pathological conditions including atopic dermatitis. In our study, human blood plasma miRNAs were identified by high‐throughput sequencing and compared among patients of atopic dermatitis and healthy controls. We found that miR‐151a was differentially expressed in the plasma of atopic dermatitis patients. MiR‐151a regulates the expression of IL12RB2 by targeting two loci in the 3′ untranslated region of the Il12rb2 gene. Moreover, IL12RB2 was remarkably downregulated in Jurkat cells overexpressing miR‐151a. Jurkat cells treated with phytohemagglutinin also showed reduced expression of IFN‐γ, interleukin‐2 (IL‐2) and IL‐12. Together, these results suggest that miR‐151a is involved in the pathogenesis of atopic dermatitis by regulating IL12RB2.
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