Early-life environmental exposures interact with genetic susceptibility variants in pediatric patients with eosinophilic esophagitis
ET Jensen, JT Kuhl, LJ Martin, CD Langefeld… - Journal of Allergy and …, 2018 - Elsevier
Background Although eosinophilic esophagitis (EoE) is associated with certain gene
variants, the rapidly increasing incidence of EoE suggests that environmental factors
contribute to disease development. Objective We tested for gene-environment interaction
between EoE-predisposing polymorphisms (within TSLP, LOC283710/KLF13, CAPN14,
CCL26, and TGFB) and implicated early-life factors (antibiotic use in infancy, cesarean
delivery, breast-feeding, neonatal intensive care unit [NICU] admission, and absence of pets …
variants, the rapidly increasing incidence of EoE suggests that environmental factors
contribute to disease development. Objective We tested for gene-environment interaction
between EoE-predisposing polymorphisms (within TSLP, LOC283710/KLF13, CAPN14,
CCL26, and TGFB) and implicated early-life factors (antibiotic use in infancy, cesarean
delivery, breast-feeding, neonatal intensive care unit [NICU] admission, and absence of pets …