The genetic basis of eosinophilic esophagitis
PMA Sleiman, M March, H Hakonarson - Best Practice & Research Clinical …, 2015 - Elsevier
Eosinophilic esophagitis is characterized by destructive responses of the immune system to
environmental allergens, including food, on the human esophagus. EoE is now reported as
a major cause of upper gastrointestinal morbidity in children and adults and the incidence is
reported to be on the increase. It is known that EoE has a high degree of heritability, with a
majority of the phenotypic variation believed to be genetic in origin as shown by genetic
epidemiology studies of twins and families. Prior to 2010, there were no known genetic risk …
environmental allergens, including food, on the human esophagus. EoE is now reported as
a major cause of upper gastrointestinal morbidity in children and adults and the incidence is
reported to be on the increase. It is known that EoE has a high degree of heritability, with a
majority of the phenotypic variation believed to be genetic in origin as shown by genetic
epidemiology studies of twins and families. Prior to 2010, there were no known genetic risk …