Physiological and pathological functions of NADPH oxidases during myocardial ischemia–reperfusion

S Matsushima, H Tsutsui, J Sadoshima - Trends in cardiovascular medicine, 2014 - Elsevier
Oxidative stress, the presence of reactive oxygen species (ROS) in excess of the antioxidant
capacity in the heart induces myocardial damage, accumulation of which leads to ischemic
heart disease and heart failure. NADPH oxidase (Nox) 2 and 4 are the major sources of O
2− and H 2 O 2 in the heart and play a crucial role in the regulation of growth and death in
cardiomyocytes. Both Nox2 and Nox4 are upregulated in response to ischemia–reperfusion
(I/R), thereby contributing to ROS production and consequent myocardial injury …