Distinct behavior of human Langerhans cells and inflammatory dendritic epidermal cells at tight junctions in patients with atopic dermatitis
K Yoshida, A Kubo, H Fujita, M Yokouchi, K Ishii… - Journal of allergy and …, 2014 - Elsevier
Background The stratum corneum and tight junctions (TJs) form physical barriers in the
epidermis. Dendrites of activated Langerhans cells (LCs) extend beyond the TJs to capture
external antigens in mice. LCs and inflammatory dendritic epidermal cells (IDECs) are
observed in the skin of patients with atopic dermatitis (AD). Objective We sought to
investigate the characteristics of LCs and IDECs and the distribution of their antigen capture
receptors in relation to TJs in normal and AD skin. Methods We characterized the …
epidermis. Dendrites of activated Langerhans cells (LCs) extend beyond the TJs to capture
external antigens in mice. LCs and inflammatory dendritic epidermal cells (IDECs) are
observed in the skin of patients with atopic dermatitis (AD). Objective We sought to
investigate the characteristics of LCs and IDECs and the distribution of their antigen capture
receptors in relation to TJs in normal and AD skin. Methods We characterized the …