[HTML][HTML] Increase in short-chain ceramides correlates with an altered lipid organization and decreased barrier function in atopic eczema patients [S]
M Janssens, J van Smeden, GS Gooris, W Bras… - Journal of lipid …, 2012 - ASBMB
A hallmark of atopic eczema (AE) is skin barrier dysfunction. Lipids in the stratum corneum
(SC), primarily ceramides, fatty acids, and cholesterol, are crucial for the barrier function, but
their role in relation to AE is indistinct. Filaggrin is an epithelial barrier protein with a central
role in the pathogenesis of AE. Nevertheless, the precise causes of AE-associated barrier
dysfunction are largely unknown. In this study, a comprehensive analysis of ceramide
composition and lipid organization in nonlesional SC of AE patients and control subjects …
(SC), primarily ceramides, fatty acids, and cholesterol, are crucial for the barrier function, but
their role in relation to AE is indistinct. Filaggrin is an epithelial barrier protein with a central
role in the pathogenesis of AE. Nevertheless, the precise causes of AE-associated barrier
dysfunction are largely unknown. In this study, a comprehensive analysis of ceramide
composition and lipid organization in nonlesional SC of AE patients and control subjects …