Omalizumab, anti-IgE recombinant humanized monoclonal antibody, for the treatment of severe allergic asthma
W Busse, J Corren, BQ Lanier, M McAlary… - Journal of allergy and …, 2001 - Elsevier
Background: A recombinant humanized anti-IgE mAb, omalizumab, forms complexes with
free IgE, blocking its interaction with mast cells and basophils; as a consequence, it might be
effective in the treatment of asthma. Objective: The purpose of this study was to evaluate the
efficacy and safety of omalizumab in the treatment of inhaled corticosteroid–dependent
asthma. Methods: In this phase III, double-blinded, placebo-controlled trial, 525 subjects with
severe allergic asthma requiring daily inhaled corticosteroids were randomized to receive …
free IgE, blocking its interaction with mast cells and basophils; as a consequence, it might be
effective in the treatment of asthma. Objective: The purpose of this study was to evaluate the
efficacy and safety of omalizumab in the treatment of inhaled corticosteroid–dependent
asthma. Methods: In this phase III, double-blinded, placebo-controlled trial, 525 subjects with
severe allergic asthma requiring daily inhaled corticosteroids were randomized to receive …