[HTML][HTML] The B56γ3 regulatory subunit of protein phosphatase 2A (PP2A) regulates S phase-specific nuclear accumulation of PP2A and the G1 to S transition
TY Lee, TY Lai, SC Lin, CW Wu, IF Ni, YS Yang… - Journal of Biological …, 2010 - ASBMB
Protein phosphatase 2A (PP2A) is a heterotrimeric enzyme consisting of a scaffold subunit
(A), a catalytic subunit (C), and a variable regulatory subunit (B). The regulatory B subunits
determine the substrate specificity and subcellular localization of the PP2A holoenzyme.
Here, we demonstrate that the subcellular localization of the B56γ3 regulatory subunit is
regulated in a cell cycle-specific manner. Notably, B56γ3 becomes enriched in the nucleus
at the G 1/S border and in S phase. The S phase-specific nuclear enrichment of B56γ3 is …
(A), a catalytic subunit (C), and a variable regulatory subunit (B). The regulatory B subunits
determine the substrate specificity and subcellular localization of the PP2A holoenzyme.
Here, we demonstrate that the subcellular localization of the B56γ3 regulatory subunit is
regulated in a cell cycle-specific manner. Notably, B56γ3 becomes enriched in the nucleus
at the G 1/S border and in S phase. The S phase-specific nuclear enrichment of B56γ3 is …