[HTML][HTML] Chronic administration of pimozide fails to attenuate motor and pathological deficits in two mouse models of amyotrophic lateral sclerosis
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease which presently
does not have any efficient therapeutic approach. Pimozide, a Food and Drug Administration
(FDA)-approved neuroepileptic drug, has been recently proposed as a promising treatment
for ALS patients based on apparent stabilization of right hand muscles after a short-time
administration. A new clinical trial started at the end of 2017 to recruit patients with a
prolonged drug delivery schedule. Here, our aim was to investigate the effects of chronic …
does not have any efficient therapeutic approach. Pimozide, a Food and Drug Administration
(FDA)-approved neuroepileptic drug, has been recently proposed as a promising treatment
for ALS patients based on apparent stabilization of right hand muscles after a short-time
administration. A new clinical trial started at the end of 2017 to recruit patients with a
prolonged drug delivery schedule. Here, our aim was to investigate the effects of chronic …