Selective suppression of hippocampal ripples impairs spatial memory
G Girardeau, K Benchenane, SI Wiener… - Nature …, 2009 - nature.com
Nature neuroscience, 2009•nature.com
Sharp wave–ripple (SPW-R) complexes in the hippocampus-entorhinal cortex are believed
to be important for transferring labile memories from the hippocampus to the neocortex for
long-term storage. We found that selective elimination of SPW-Rs during post-training
consolidation periods resulted in performance impairment in rats trained on a hippocampus-
dependent spatial memory task. Our results provide evidence for a prominent role of
hippocampal SPW-Rs in memory consolidation.
to be important for transferring labile memories from the hippocampus to the neocortex for
long-term storage. We found that selective elimination of SPW-Rs during post-training
consolidation periods resulted in performance impairment in rats trained on a hippocampus-
dependent spatial memory task. Our results provide evidence for a prominent role of
hippocampal SPW-Rs in memory consolidation.
Abstract
Sharp wave–ripple (SPW-R) complexes in the hippocampus-entorhinal cortex are believed to be important for transferring labile memories from the hippocampus to the neocortex for long-term storage. We found that selective elimination of SPW-Rs during post-training consolidation periods resulted in performance impairment in rats trained on a hippocampus-dependent spatial memory task. Our results provide evidence for a prominent role of hippocampal SPW-Rs in memory consolidation.
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