Apoptosis, fas and systemic autoimmunity: the MRL-Ipr/Ipr model
GG Singer, AC Carrera, A Marshak-Rothstein… - Current Opinion in …, 1994 - Elsevier
GG Singer, AC Carrera, A Marshak-Rothstein, C Martínez-A, AK Abbas
Current Opinion in Immunology, 1994•ElsevierProteins encoded by the fas and fas ligand (fasL) genes are involved in apoptotic cell death
in lymphocytes. In this article we review the recent elucidation of the role of the Fas-Fast
interactions in the maintenance of tolerance to self antigens and in the homeostatic
regulation of lymphocyte clonal expansion, and discuss the mechanisms of autoimmunity in
Fas-and FasL-deficient mutant mouse strains.
in lymphocytes. In this article we review the recent elucidation of the role of the Fas-Fast
interactions in the maintenance of tolerance to self antigens and in the homeostatic
regulation of lymphocyte clonal expansion, and discuss the mechanisms of autoimmunity in
Fas-and FasL-deficient mutant mouse strains.
Abstract
Proteins encoded by the fas and fas ligand (fasL) genes are involved in apoptotic cell death in lymphocytes. In this article we review the recent elucidation of the role of the Fas-Fast interactions in the maintenance of tolerance to self antigens and in the homeostatic regulation of lymphocyte clonal expansion, and discuss the mechanisms of autoimmunity in Fas- and FasL-deficient mutant mouse strains.
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