[HTML][HTML] Structural requirements for signal-induced target binding of FADD determined by functional reconstitution of FADD deficiency
HZ Imtiyaz, Y Zhang, J Zhang - Journal of Biological Chemistry, 2005 - ASBMB
FADD is a key adaptor modulating several signaling pathways such as apoptosis induced
by Fas (CD95) and tumor necrosis factor receptor 1, and cell proliferation induced by
mitogens. Whereas mutations in Fas disrupt its binding to FADD and cause autoimmune
lymphoproliferative (lpr) syndromes, a FADD deficiency blocks embryonic development in
mice. To delineate the multifunction of FADD in vivo, we performed functional reconstitution
analysis by introducing wild type and mutant FADD into FADD–/–cells or FADD–/–mice …
by Fas (CD95) and tumor necrosis factor receptor 1, and cell proliferation induced by
mitogens. Whereas mutations in Fas disrupt its binding to FADD and cause autoimmune
lymphoproliferative (lpr) syndromes, a FADD deficiency blocks embryonic development in
mice. To delineate the multifunction of FADD in vivo, we performed functional reconstitution
analysis by introducing wild type and mutant FADD into FADD–/–cells or FADD–/–mice …