[HTML][HTML] Complexity of bone marrow hematopoietic stem cell niche

N Asada, S Takeishi, PS Frenette - International journal of hematology, 2017 - Springer
International journal of hematology, 2017Springer
Hematopoietic stem cells (HSCs) that produce a variety of hematopoietic lineage cells
throughout the life reside in specialized microenvironment called “niche” in the bone marrow
(BM) where they are tightly regulated. With the recent advances in experimental
technologies enabling the selective deletion of molecules, various types of cells in the BM
have been proposed to contribute to HSC niche activity. Among these are stromal cells
closely associated with the vasculature. In this review, we provide an overview of recent …
Abstract
Hematopoietic stem cells (HSCs) that produce a variety of hematopoietic lineage cells throughout the life reside in specialized microenvironment called “niche” in the bone marrow (BM) where they are tightly regulated. With the recent advances in experimental technologies enabling the selective deletion of molecules, various types of cells in the BM have been proposed to contribute to HSC niche activity. Among these are stromal cells closely associated with the vasculature. In this review, we provide an overview of recent advances in HSC niche research, and focus on the studies describing the functional roles of perivascular cells for HSC maintenance and mobilization. Not only for physiologic state, we also discuss the recent evidences suggesting the importance of microenvironment for emergence of malignant hematopoietic diseases.
Springer