Adaptation of Pseudomonas aeruginosa during persistence in the cystic fibrosis lung
M Hogardt, J Heesemann - International Journal of Medical Microbiology, 2010 - Elsevier
The long-term persistance of P. aeruginosa in the cystic fibrosis (CF) lung is characterized
by the selection of a variety of genotypes and phenotypes that typically descend from one
infecting P. aeruginosa clone, a process known as adaptive radiation. This adaptation
process of P. aeruginosa includes complex physiological changes that likely confer a
selective advantage to better thrive in the diverse niches and microenvironments of the
inflamed and hostile CF airways. The occurrence of P. aeruginosa variants is fixed by …
by the selection of a variety of genotypes and phenotypes that typically descend from one
infecting P. aeruginosa clone, a process known as adaptive radiation. This adaptation
process of P. aeruginosa includes complex physiological changes that likely confer a
selective advantage to better thrive in the diverse niches and microenvironments of the
inflamed and hostile CF airways. The occurrence of P. aeruginosa variants is fixed by …